Molecular Testing Labs will allow the patient to truly understand how his or her body absorbs and metabolizes the many drugs available today used to treat cholesterol, heart conditions, blood conditions related to strokes, and other cardiovascular conditions. This easy-to-understand test will help the patient and physician to avoid or lessen the adverse side effects that are common with these types of drugs. Every patient responds differently to drugs and should be treated individually!
Different genes regulate how fast or slow various drugs are metabolized. Some people metabolize certain types of drugs very quickly and some people very slowly, which can cause problems with side effects and toxicity. The most common genes affecting drug metabolism are called Cytochrome P450 (CYP450). This group includes genes that code for an important liver enzyme that is active in the metabolism of toxins, metabolic intermediates, lipids, sterols and xenobiotic substances such as drugs. These enzymes account for 75% of the processes involved in the metabolism and the bioactivation of all drugs.
The Cardiac Drug Interaction Panel from Molecular Testing Labs identifies five different types of patients and the way they metabolize certain drugs.
- Normal Metabolizers (NM)
- Poor Metabolizers (PM)
- Intermediate Metabolizers (IM)
- Rapid Metabolizers (RM)
- Ultra Rapid Metabolizers (URM)
Approximately 15% of all prescribed drugs, including common drugs such as clopidogrel (Plavix), propafenone (Rythmol SR, Rytmonorm), omeprazole (Prilosec), sertraline (Zoloft, Lustral), citalopram (Celexa, Cipramil), and diazepam (Valium) are affected by small mutations in CYP450. In individuals with a small mutation, some drugs may be activated or metabolized more slowly than in individuals with the normal gene. Other drugs may be metabolized or activated more quickly. Detecting these genetic variations in the drug-metabolizing enzymes is useful for individuals and clinicians to detect help predict which individuals may experience adverse reactions for these types of drugs. Clopidogrel (Plavix) is an example of a drug that reduces the chance of a harmful blood clot. Once inside the body, clopidogrel is absorbed in the intestines and then converted into its active form by enzymes in the liver. But some people have genetic variations that reduce the activity of one of the most critical enzymes. Studies have shown that people who need clopidogrel but have these enzymatic variations are at increased risk of heart attacks, strokes and death from cardiovascular causes compared to those whose genetics enables them to metabolize the drug. The Molecular Testing Labs is proud to provide you with the option to select only those groupings of drugs that are of importance to you. Please just select which column of drugs that you would like to have analyzed and place those selections into the cart. Molecular Testing Labs will do the rest and provide you with a comprehensive analysis of how your body responds to these particular drugs on a genetic level.
Molecular Testing Labs provides CONFIDENTIAL screening through DNA sampling of the cheek by the use of a buccal swab technique. It is easy, fast and painless, and can be
performed at home. Simply choose this test in your shopping cart and we will mail you a confidential sample kit the next day. Following receipt of the sample, we will deliver your laboratory report via your preferred method in 3 days.
Molecular Testing Labs strongly recommends that you consult with your personal physician following completion of this molecular test. The Cardiac Drug Interaction Panel molecular test is a key component to “Helping You Help Yourself.” Molecular Testing Labs’ philosophy is that patients should be informed and in control of their own healthcare. We are proud to be part of your healthcare team, providing you, in partnership with your personal physician, with some of the tools you need to take charge of your own health.